In this webinar, Dr. Dzmitry Mukha, Postdoctoral Research Fellow at The Wistar Institute, introduced solutions to:
- A metabolic systems biology approach was employed to study the role of the glycine cleavage system (GCS) and glycine decarboxylase (GLDC) in hepatocellular carcinoma (HCC)
- HCC exhibits high expression of GCS genes and high glycine cleavage metabolic flux
- MitoPlate™ analysis of GLDC-silenced cells demonstrated a decrease in pyruvate and α-ketoglutarate oxidation caused by decreased lipoylation of mitochondrial enzyme
- Genetic silencing of GLDC impairs tumor growth, suggesting a novel drug target for HCC
