In my lab, we focus on using clinically relevant systems such as 3-Dimensional co-cultures to study cancer and its interaction with the microenvironment.  Specifically, pathways involved in redox signaling and DNA repair through APE1/Ref-1 under conditions of hypoxia are interrogated as therapeutic targets.  We use the Biolog’s S-1 MitoPlates to evaluate effects of Ref- inhibition on mitochondrial function.