Metabolic Virulence Determinants in Haemophilus influenzae

Metabolic Virulence Determinants in Haemophilus influenzae

In this webinar, Dr. Ulrike Kappler, Associate Professor in Biochemistry and Molecular Biology, School of Chemistry and Molecular Biosciences, The University of Queensland, introduced solutions to:

  • Phenotype MicroArrayâ„¢ analysis of Haemophilus influenzae strains revealed a highly specialized metabolic profile with lactate as the preferred carbon source

  • L-Lactate metabolism leads to the production of the immunometabolite acetate, while D-Lactate conversions are used for redox balancing

  • Lactate utilization is essential for H. influenzae survival in host organisms, and acetate production modulates the host response to infection