Biolog invites you to a special webinar featuring our guest speaker:
Dr. JN Rashida Gnanaprakasam
Center for Childhood Cancer and Blood Diseases
Abigail Wexner Research Institute
Nationwide Children’s Hospital
Ohio State University
Webinar Topics Include:
- Discovery of an inosine metabolic pathway that provides for the nutritional needs of T cells following activation under glucose restriction
- The essential role of inosine and purine nucleoside phosphorylase (PNP) in survival of T cells versus cancer cells
- Demonstration that inosine treated T cells can extend life of mice with implanted tumors that are defective in metabolizing inosine
- Potential of inosine to enhance cancer immunotherapy by improving metabolic fitness of T cells and overcoming immunosuppressive barriers in the tumor microenvironment
