Biolog Phenotype MicroArray
     Serious Technology for Serious Microbiology April 2008

Useful Links

Phenotype MicroArray Services would like to recognize the success of Biolog's PM customers over the last few years. The links below point to interesting and important select published work across many genera and applications.

Phenotype MicroArrays now work with most genera. For information on using Phenotype MicroArray Services in your research, click here: Phenotype MicroArray Services Webpage or contact us directly at 510-670-3370

Abstracts from the Florence Conference on Phenotype MicroArray Analysis of Microorganisms

Phenotype MicroArray
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A previously undescribed pathway for pyrimidine catabolism

Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S. Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720-3102, USA. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. Epub 2006 Mar 15.
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  Requirement of the dephospho-form of enzyme IIA for derepression of Escherichia coli K-12 ilvBN expression
Lee CR, Koo BM, Cho SH, Kim YJ, Yoon MJ, Peterkofsky A, Seok YJ. Laboratory of Macromolecular Interactions, Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 151-742, Korea. Mol Microbiol. 2005 Oct;58(1):334-44.
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Detection of Salmonella enterica subpopulations by phenotype microarray antibiotic resistance patterns

Guard-Bouldin J, Morales CA, Frye JG, Gast RK, Musgrove M. U.S. Department of Agriculture, Agricultural Research Service, Egg Safety and Quality Research Unit, 950 College Station Road, Athens, GA 30605, USA. . Appl Environ Microbiol. 2007 Dec;73(23):7753-6. Epub 2007 Oct 26.
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  Correlation of phenotype with the genotype of egg-contaminating Salmonella enterica serovar Enteritidis
Morales CA, Porwollik S, Frye JG, Kinde H, McClelland M, Guard-Bouldin J. Egg Safety and Quality Research Unit, Agricultural Research Service, U.S. Department of Agriculture, 950 College Station Rd., Athens, GA 30605, USA. Appl Environ Microbiol. 2005 Aug;71(8):4388-99.
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Genomic and phenotypic diversity of coastal Vibrio cholerae strains is linked to environmental factors

Keymer DP, Miller MC, Schoolnik GK, Boehm AB. Department of Civil Engineering, Stanford University School of Medicine, CA 94305, USA. Appl Environ Microbiol. 2007 Jun;73(11):3705-14. Epub 2007 Apr 20.
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Characterization of chromate-resistant and -reducing bacteria by traditional means and by a high-throughput phenomic technique for bioremediation purposes

Viti C, Decorosi F, Tatti E, Giovannetti L. Dipartimento di Biotecnologie Agrarie, Sezione di Microbiologia, Università degli Studi di Firenze, Piazzale delle Cascine 24, I-50144, Firenze, Italy. Biotechnol Prog. 2007 May-Jun;23(3):553-9. Epub 2007 Mar 27.
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  Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa
Li W, Lu CD. Department of Biology, Georgia State University, 24 Peachtree Center Ave., Atlanta, GA 30303, USA. J Bacteriol. 2007 Aug;189(15):5413-20. Epub 2007 Jun 1.
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  Dual involvement of CbrAB and NtrBC in the regulation of histidine utilization in Pseudomonas fluorescens SBW25
Zhang XX, Rainey PB. Institute of Molecular Biosciences, Massey University, Auckland, New Zealand. Genetics. 2008 Jan;178(1):185-95.
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Beta-D-Allose inhibits fruiting body formation and sporulation in Myxococcus xanthus

Chavira M, Cao N, Le K, Riar T, Moradshahi N, McBride M, Lux R, Shi W. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095-1668, USA. J Bacteriol. 2007 Jan;189(1):169-78. Epub 2006 Oct 20.
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Lactobacillus buchneri strain NRRL B-30929 converts a concentrated mixture of xylose and glucose into ethanol and other products

Liu S, Skinner-Nemec KA, Leathers TD. Bioproducts and Biocatalysis Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 N. University St, Peoria, IL, 61604, USA, J Ind Microbiol Biotechnol. 2008 Feb;35(2):75-81. Epub 2007 Oct 17.
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Role of HtrA in surface protein expression and biofilm formation by Streptococcus mutans

Biswas S, Biswas I. Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, 57069-2390, USA. Infect Immun. 2005 Oct;73(10):6923-34.
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Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data

Oh YK, Palsson BO, Park SM, Schilling CH, Mahadevan R. Department of Bioengineering, University of California at San Diego, La Jolla, California 92093-0412, USA. J Biol Chem. 2007 Sep 28;282(39):28791-9. Epub 2007 Jun 15.
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  Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors
Mascher T, Hachmann AB, Helmann JD. Department of Microbiology, Wing Hall, Cornell University, Ithaca, NY 14853-8101, USA. J Bacteriol. 2007 Oct;189(19):6919-27. Epub 2007 Aug 3.
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  Saccharomyces/filamentous fungi
Carbon source dependence and photostimulation of conidiation in Hypocrea atroviridis

Friedl MA, Kubicek CP, Druzhinina IS. Research Area of Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, Getreidemarkt 9-1665, A-1060 Vienna, Austria. Appl Environ Microbiol. 2008 Jan;74(1):245-50. Epub 2007 Nov 2. Microbiology. 2006 Jul;152(Pt 7):2003-12.
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  A screening system for carbon sources enhancing beta-N-acetylglucosaminidase formation in Hypocrea atroviridis (Trichoderma atroviride)
Seidl V, Druzhinina IS, Kubicek CP. Research Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, TU Vienna, Austria. Microbiology. 2006 Jul;152(Pt 7):2003-12.
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  Global carbon utilization profiles of wild-type, mutant, and transformant strains of Hypocrea jecorina
Druzhinina IS, Schmoll M, Seiboth B, Kubicek CP. Research Area of Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, Getreidemarkt 9-1665, A-1060 Vienna, Austria. Appl Environ Microbiol. 2006 Mar;72(3):2126-33.
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  Harnessing natural diversity to probe metabolic pathways
Homann OR, Cai H, Becker JM, Lindquist SL. Committee on Genetics, University of Chicago, Chicago, Illinois, United States of America. PLoS Genet. 2005 Dec;1(6):e80. Epub 2005 Dec 30.
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Phenotype MicroArray Technology
Biolog's Phentoype MicroArray technology enables researchers to evaluate nearly 2000 phenotypes of a microbial cell in a single experiment. This integrated system of cellular assays, instrumentation and bioinformatics software provides cellular knowledge that complements molecular information, helping you interpret and find the relevant aspects in massive amounts of gene expression or proteomics data. Through comprehensive and precise quantitation of phenotypes, researchers are able to obtain an unbiased perspective of the effect on cells of genetic differences, environmental change, exposure to chemicals or drugs, and more.