PMs can be applied at multiple stages in the
drug discovery process, providing researchers
with better information to help make better
decisions. With PMs the entire process becomes
faster and more efficient.
The current drug discovery
and development process is long and expensive.
Just consider:
Only one compound of 10,000
makes it to market
It can take upwards of
15 years and $800 million to commercialize
a single drug
The challenge
for drug companies is three-fold: reduce product
development costs… decrease time to market…
and increase the probability of success for
the most promising leads. Biolog’s PM
technology can assist with these three challenges
-- and more.
Uses
for
PMs
Discover
genes
that are
drug
targets
Characterize
and discriminate
biological
function of targets
HTS Screening
of drug
leads
Evalutate leads
for optimal
pharmacologic
efficacy &
selectivity
The
genomic revolution has delivered massive amounts
of data about life’s molecular components,
moving the bottleneck in drug discovery downstream
by giving drug discovery organizations more
qualified targets and leads than ever before.
However, there remains a barrier in going
from molecular data to understanding what
really happens in living cells. PMs
provide the needed technology to complement
molecular genomics and cross that barrier
(see diagram below).
Affymetrix
1993
O'Farrell
1975
Biolog
2001
Molecular Analyses
Cellular
Analysis
Just as genomics and proteomics have made
it possible to measure levels of than sounds
of genes and proteins all at once, Biolog’s
new PM technology, can quantitatively measure
thousands of cellular phenotypes in one
analysis. This provides the technological
transition over the barrier from molecular
to cellular analysis.
Impact on the
Drug Discovery Process
Continuing
innovations in genomics and analytical
technologies have made it particularly
difficult for pharmaceutical and biotechnology
organizations to determine the optimum
approach to employ in the drug discovery
process.
Biolog
has demonstrated that Phenotype MicroArray
technology has the ability to deliver
significant benefits at multiple stages
in the drug discovery process:
Permits
direct cellular assay
of gene function
Complements
genetic and molecular
methods
and extends existing
gene expression data
Provides
analysis of genetic
mutations
Identifies
metabolic pathways and
may include
enzyme specific targeting
Allows
efficient evaluation
of drug leads
Allows
direct observation of
a drug’s primary
and secondary effects
at the cellular level
Reduces
need for expensive,
slow animal / plant
models
The
result of using PM technology? More
promising druggable leads and a reduction
in failure rates.
PMs help drug companies to choose the
right drug leads for animal and
human testing, saving time, money by
lowering the opportunity cost associated
with bad
decisions.
Brochure
on Using PM Technology in Drug Discovery To view a document providing
an overview of PM technology applied
to drug discovery click
here to view and download
a pdf file.
Mechanism of Action (MOA) of
Antimicrobials To view a document on Using
PM Technology in Antimicrobial MOA
Studies click
here to view and download
a pdf file
Structure Activity Relationship
(SAR) Analysis To view a document on Using
PM Technology to Guide SAR Studies click
here to view and download
a pdf file
If you would like to request a packet
of information, including a brochure
on PM technology
and drug discovery, please register with Biolog.
Cellular
Analysis
